J Clin Psychopharmacol 2016;36(6):572-9. View abstract. Bai, Y. S., Zhou, C. Y., and Wang, J. Q. 2000;20(1):38-41. View abstract. Back to the Blog. An open study of 100 women with uterine fibroids showed that peony reduced the size of . Some medications are changed and broken down by the liver. View abstract. Yuan, H. N., Wang, C. Y., Sze, C. W., Tong, Y., Tan, Q. R., Feng, X. J., Liu, R. M., Zhang, J. N Engl J Med 1990;322:850. This information may not fit your specific health circumstances. Some medications are moved in and out of cells by pumps. Zhou Y, Jin L, Kong F, et al. J Pharmacobiodyn 1984;7:304-11. The Potential Benefits and Side Effects of the White Peony Root. Drug Metab Dispos 2015;43(7):1147-53. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). View abstract. Peony root might decrease the amount of phenytoin in the body. The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient. Gen Dent 2008;56(2):206-210. Medicinal uses of licorice through the millennia: the good and plenty of it. Hawrelak, J. Exp Clin Endocrinol Diabetes 2003;111:341-3. Ned.Tijdschr Geneeskd. Dong quai grows at high altitudes in the cold, damp, mountains of China, Korea, and Japan. Black licorice can have serious side effects when eaten in large amounts. Hsu, Y. L., Wu, L. Y., Hou, M. F., Tsai, E. M., Lee, J. N., Liang, H. L., Jong, Y. J., Hung, C. H., and Kuo, P. L. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. Liquorice-induced rise in blood pressure: a linear dose-response relationship. View abstract. An Med Interna 1995;12(1):33-35. View abstract. Effects of chalcones isolated from licorice roots on leukotriene biosynthesis in human polymorphonuclear neutrophils. It may disrupt the production of sex hormones ( 9 ). View abstract. Exp Med Surg 1969;27:411-20. [Effectiveness of interferon, glycyrrhizin combination therapy in patients with chronic hepatitis C]. View abstract. Apparantly it's the one most important thing that shouldn't mix with Prednisolone and it makes withdrawal symptoms much worse. But not everyone will have the side . 2005 - 2023 WebMD LLC. Zhong Xi Yi Jie He Za Zhi 1991;11(3):150-2, 133. J Biol Response Mod 1985;4:551-84. [RETRACTED]. View abstract. Bronson Korean Panax Ginseng 1000 mg Supports Energy, Endurance & Vitality + Memory and Mental Performance, 120 Capsules. Riv Patol Nerv Ment 1983;104(4):179-183. Although white peony is generally considered safe for most people, drinking large amounts might have some negative consequences. Ital J Neurol Sci 1983;4(4):493-497. October 15, 2021. 1979;14(5):605-607. Microbiol Immunol 2000;44(9):799-804. Sakamoto, S., Yoshino, H., Shirahata, Y., Shimodairo, K., and Okamoto, R. Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas. View abstract. Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials. Int J Nurs Stud 2016;63:9-17. Phytother Res 2008;22(2):141-148. View abstract. Little is known about whether it's safe to use licorice root while breastfeeding. Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. Am J Epidemiol 2002;156:803-5.. View abstract. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: Aspirin; Clopidogrel; Warfarin; St. John's wort. View abstract. Okubo T, Nagai F, Seto T, et al. View abstract. Luchon, L., Meyrier, A., and Paillard, F. [Hypokalemia without arterial hypertension by licorice poisoning]. Nephron 2002;90:240. A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers. Results of a double-blind placebo controlled comparative study]. White peony ( bai shao in Chinese) is root without any bark, while red peony . Contact Dermatitis 1989; 20:152-3.. View abstract. OTHER NAME(S): Bai Shao, Chi Shao, Chinese Peony, Common Peony, C. Peony (Paeonia lactiflora) is an herb. Drug Metab Dispos 2002;30:709-15.. View abstract. J Cosmet.Sci 2006;57(1):57-64. View abstract. Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11. Biol Pharm Bull 1998;21:1277-81. Complement Ther Clin Pract. View abstract. Minerva Med 2008;99(1):91-94. 2000;20(3):173-175. Zhang W, Leonard T, Bath-Hextall F, et al. View abstract. Ir J Med Sci 2016;185(4):945-7. WebMD does not provide medical advice, diagnosis or treatment. Peony-glycyrrhiza decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. View abstract. The chemicals in licorice are thought to . Antiviral Res 1987;7(3):127-137. J Altern Complement Med 2010;16(10):1065-1071. View abstract. Qi XG. J Clin Periodontol 1991;18(3):210-212. Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. One major reported side effect of licorice root is reduced levels of testosterone in men ( 10 ). 2010;33(2):321-324. Werner, S., Brismar, K., and Olsson, S. Hyperprolactinaemia and liquorice. therapy. Nephol Dial Transplant 1999;14:218-20. The effects of dietary licorice flavonoid oil supplementation on body balance control in healthy middle-aged and older Japanese women undergoing a physical exercise intervention: a randomized, double-blind, placebo-controlled trial. Exp Ther Med 2016;11(3):1135-41. A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers or health and adiposity. Bannister, B., Ginsburg, R., and Shneerson, J. Cardiac arrest due to liquoriceinduced hypokalaemia. [Comparison of pre- and post-treatmental hepatohistology with heavy dosage of Paeonia rubra on chronic active hepatitis caused liver fibrosis]. Peony and Licorice - Radiant Wonder Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A. Zhong Xi Yi Jie He Za Zhi 1986;6:714-6, 707. Fuhrman, B., Volkova, N., Kaplan, M., Presser, D., Attias, J., Hayek, T., and Aviram, M. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. Paeonia lactiflora : Peony is another popular anti-androgenic herb. 2020 Dec;58(1):352-356. Cotterill, J. 2012;18(4):534-543. View abstract. van Rossum, T. G., Vulto, A. G., Hop, W. C., Brouwer, J. T., Niesters, H. G., and Schalm, S. W. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. View abstract. Phytomedicine 2003;10:271-85. Zhong Xi Yi Jie He Za Zhi 1991;11:102-4, 69. View abstract. van der Zwan A. Sigurjonsdottir HA, Franzson L, Manhem K, et al. Wu G, Wu N, Li T, et al. J Pharmacol Exp Ther 2006;316:1369-77. Life Sci 2-23-2001;68(14):1687-1694. Am J Chin Med 1996;24:165-8. Kumada T, et al. Z Kardiol 1991;80(6):389-391. 1. There are studies with assisted nutrients to expedite healing and mitigate side effects of hormone imbalances associated with IVF/IUI discussed below. In general, the safety and effectiveness of alternative medicines have not been scientifically proven and remain largely unknown. Phytother Res 1988;2(3):140-145. Br J Dermatol 1992;126:179-84. O'Connell K, Kinsella J, McMahon C, Holian J, O'Riordan S. Posterior reversible encephalopathy syndrome (PRES) associated with liquorice consumption. The efficacy and safety of the combination of total glucosides of peony and leflunomide for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. View abstract. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. View abstract. Muscle cramps.Early research suggests that taking a specific combination of peony and licorice (Shakuyaku-kanzoh-to) might ease muscle cramps in people with liver cirrhosis and in people undergoing hemodialysis. Drugs & Vitamins . Iran J Pharm Res 2012;11(2):541-8. Hukkanen J, Ukkola O, Savolainen MJ. View abstract. A., Lee, S. H., and Lee, S. M. Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Am J Respir.Cell Mol.Biol. View abstract. Steinberg, D., Sgan-Cohen, H. D., Stabholz, A., Pizanty, S., Segal, R., and Sela, M. N. The anticariogenic activity of glycyrrhizin: preliminary clinical trials. 6 Top Celery Juice Benefits & Side Effects. Yorgun, H., Aksoy, H., Sendur, M. A., Ates, A. H., Kaya, E. B., Aytemir, K., and Oto, A. Brugada syndrome with aborted sudden cardiac death related to liquorice-induced hypokalemia. N Engl J Med. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. View abstract. Bian, X., Xu, Y., Zhu, L., Gao, P., Liu, X., Liu, S., Qian, M., Gai, M., Yang, J., and Wu, Y. This can be severe. Immunopharmacology 1999;41(3):169-181. It's thought liquorice's side-effects are caused by the glycyrrhizic acid, but it is possible to buy deglycyrrhizinated liquorice (DGL), which may help prevent these issues. and its bioactive compounds. J Am Soc Nephrol 2002;13(1):191-196. Isaia, G. C., Pellissetto, C., Ravazzoli, M., and Tamone, C. Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses. White Peony is technically named Peonia lactiflora, and in Chinese, it is named Bai Shao. View abstract. View abstract. View abstract. Licorice | Complementary and Alternative Medicine | St. Luke's Hospital Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Braz J Infect Dis 2016;20(6):534-8. J Clin Psychopharmacol 1997;17(3):234-235. Lancet 1992;340:13-17. Licorice roots can be consumed directly to get relief from cough and sore throat. Brasseur, A. and Ducobu, J. Am J Chin Med 2003;31:445-53. . Russo S, Mastropasqua M, Mosetti MA, et al. Nippon Rinsho 1994;52:1817-22. 2016 Nov;48(11):1873-1880. doi: 10.1007/s11255-016-1345-5. 2020;2020:3727682. In a 30-day study in 50 adults with indigestion, taking a 75-mg licorice . A multicentre trial. Phytother Res. View abstract. Hyodo T, Taira T, Kumakura M, et al. Costa, A., Moises, T. A., Cordero, T., Alves, C. R., and Marmirori, J. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. Some medications are changed and broken down by the liver. Peony for Women's Health and Beyond Radix Paeoniae Alba increases serum estrogen level and up-regulates estrogen receptor expression in uterus and vagina of immature/ovariectomized mice. Because of its beneficial effects, the licorice root has been dubbed the "Medicinal plant of 2012." Now scientists have discovered that licorice root from the papilionaceae or leguminous family . View abstract. Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis -- double blind trial. View abstract. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. Neth J Med 2005;63:119-20. [Study on activating blood and eliminating stasis of total paeony glycoside(TPG)]. View abstract. Ann Pharmacother 2003;37(6):836-838. J Assoc Physicians India 1978;26(9):811-814. View abstract. Lancet 2003;361:2045-6.. View abstract. A newly-filed federal lawsuit claims eating too much of The Hershey Company's Good & Plenty and black licorice Twizzlers candies can cause serious health problems, maybe even death. Eur J Dermatol. View abstract. Ito, M., Nakashima, H., Baba, M., Pauwels, R., De Clercq, E., Shigeta, S., and Yamamoto, N. Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV- III/LAV)]. But, she survived . Taking licorice might reduce the effects of blood pressure medications. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. View abstract. Cardiovasc.Drugs Ther 1998;12(6):599-600. The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial. Lethal liquorice lollies (liquorice abuse causing pseudohyperaldosteronism). Licorice seems to change hormone levels in the body. Nussbaumer, U., Landolt, M., Rothlisberger, G., Akovbiantz, A., Keller, H., Weber, E., Blum, A. L., and Peter, P. [Postoperative stress hemorrhage: ineffective prevention with pepsin inhibitor and deglycyrrhizinized licorice extract. Serra, A., Uehlinger, D. E., Ferrari, P., Dick, B., Frey, B. M., Frey, F. J., and Vogt, B. Glycyrrhetinic Acid decreases plasma potassium concentrations in patients with anuria. Akbari N, Asadimehr N, Kiani Z. Guo TL, Zhou XW. View abstract. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. 2004;24(12):1084-1086. Some sources claim that it's contraindicated during pregnancy . Taking peony along with birth control pills might increase the risk of side effects. Astragalus | NCCIH Francini-Pesenti F, Puato M, Piccoli A, Brocadello F. Liquorice-induced hypokalaemia and water retention in the absence of hypertension. Red Peony Root (Paeniae Rubra Radix) 8 g Myrrh (Myrrha) . Cumming, A. M., Boddy, K., Brown, J. J., Fraser, R., Lever, A. F., Padfield, P. L., and Robertson, J. I. Licorice Root For PCOS: Benefits, Risks & Practical Tips Clin Rheumatol. Chem Pharm Bull (Tokyo) 1994;42(5):1056-1062. Lozenge-induced hypermineralcorticoid state--a unique case of licorice lozenges resulting in hypertension and hypokalemia. Part 2: Effect of glycyrrhizic acid on the course of illness]. Xu, L., Jiang, J., and Du, F. Z. Antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var. Shintani, S., Murase, H., Tsukagoshi, H., and Shiigai, T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Although some people believe that peony tea is the tea with the lowest caffeine levels, actually peony tea has a high caffeine level, as much as 5%. Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents. Learn more about Peony health benefits, uses, side effects, effectiveness, safety, precautions, and warnings. About Dr.Cope. Cai Y, Yuan Q, Xu K, et al. Health Benefits and Side Effects of White Peony Root - Epainassist A. Altern Med Rev 1999;4(3):178-188. Ann Noninvasive Electrocardiol. J Clin Anesth 2019;54:25-32. Hajiaghamohammadi, A. B. View abstract. View abstract. Liu X, Li X, Li X, et al. Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: A systematic review and meta-analysis. Shen, A. Y., Wang, T. S., Huang, M. H., Liao, C. H., Chen, S. J., and Lin, C. C. Antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells. PCOS; Fertility; 25 - 45; Menopause; 45 - 60; Pregnancy The Magical Root Angelica Sinensis - GaneshaSpeaks View abstract. View abstract. View abstract. O'Connell, R. L., White, I. R., White, J. M., and McFadden, J. P. Liquorice extract in a cosmetic product causing contact allergy. Acute myopathy associated with chronic licorice ingestion: reversible loss of myoadenylate deaminase activity. The 54-year-old man was in a fast food . Liu C, Wang J, Yang J. Licorice that has had this substance removed (called DGL for deglycyrrhizinated licorice) may not have the same degree of side effects. View abstract. Yu IC, Tsai YF, Fang JT, Yeh MM, Fang JY, Liu CY. White Peony Root: Potential Benefits, Side Effects, Uses - Healthline View abstract. Complement Ther Clin Pract. [Paeonia Lactiflora injection in treating chronic cor pulmonale with pulmonary hypertension]. Phytother Res 2008;22(6):709-724. Bernardi, M., D'Intino, P. E., Trevisani, F., Cantelli-Forti, G., Raggi, M. A., Turchetto, E., and Gasbarrini, G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Armanini, D., Castello, R., Scaroni, C., Bonanni, G., Faccini, G., Pellati, D., Bertoldo, A., Fiore, C., and Moghetti, P. Treatment of polycystic ovary syndrome with spironolactone plus licorice. Helpful. View abstract. Rackova, L., Jancinova, V., Petrikova, M., Drabikova, K., Nosal, R., Stefek, M., Kostalova, D., Pronayova, N., and Kovacova, M. Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin. View abstract. View abstract. Zhou, Y., Huang, Z., and Huang, T. [Clinical study of shengxue mixture in treating aplastic anemia]. Effect of glycyrrhizin on viral replication and quasispecies in patients with type C chronic hepatitis. 2019;18(Suppl1):291-301. Mechanism of anti-inflammatory action of glycyrrhizin: effect on neutrophil functions including reactive oxygen species generation. Schweiz Med Wochenschr 2-26-1977;107(8):276-279. Goto, F., Asama, Y., and Ogawa, K. Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery. Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. Front Psychiatry 2020;11:605949. 2013 Jun;19(4):227-8. Licorice is an herb that grows in parts of Europe and Asia. B., and Zhang, Z. J. Planta Med 1983;48(5):38-42. Qraa Advanced Lacto Dark Underarm Whitening Cream Product Claims Qraa underarm whitening cream claims to lighten dark underarms by reducing melanin from the skin in the area. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28(4):314-317. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. OTHER NAME(S): Acide Glycyrrhizique, Acide Glycyrrhizinique, Alca. Licorice Root: Benefits, Uses, Precautions, and Dosage - Healthline Edelman ER, Butala NM, Avery LL, Lundquist AL, Dighe AS. The efficacy and safety of total glucosides of peony in the treatment of primary Sjögren's syndrome: a multi-center, randomized, double-blinded, placebo-controlled clinical trial. Am J Chin Med 2001;29(3-4):459-467. Deglycyrrhizinated liquorice in duodenal ulcer. J Clin Psychopharmacol 2008;28(3):264-370. LICORICE - Uses, Side Effects, and More - WebMD Lee, S. M., Li, M. L., Tse, Y. C., Leung, S. C., Lee, M. M., Tsui, S. K., Fung, K. P., Lee, C. Y., and Waye, M. M. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. View abstract. Effect of shakuyaku-kanzoh-toh, a prescription composed of shakuyaku (Paeoniae Radix) and kanzoh (Glycyrrhizae Radix) on guinea pig ileum. (Doses up to 60 grams daily for up to 4 months have been used without reported adverse effects.) Pharmacotherapeutic effects of toki-shakuyaku-san on leukorrhagia in young women. Hypertension encephalopathy after liquorice ingestion. View abstract. Am J Chin Med 2005;33(5):747-758. Licorice can decrease potassium levels. All rights reserved. View abstract. Pathogenetic considerations and presentation of a clinical case]. Goultschin, J., Palmon, S., Shapira, L., Brayer, L., and Gedalia, I. Z., Zhang, Y. 2 in the perioperative stage of laparoscopic cholecystectomy]. van Rossum, T. G., Vulto, A. G., Hop, W. C., and Schalm, S. W. Pharmacokinetics of intravenous glycyrrhizin after single and multiple doses in patients with chronic hepatitis C infection. View abstract. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. Akamatsu, H., Komura, J., Asada, Y., and Niwa, Y. Practitioner 1973;210:820-3. View abstract. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Digestion 2004;69:45-52. Licorice: From Pseudohyperaldosteronism to Therapeutic Uses The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Can J Cardiol 2009;25(10):e357-e358. 1987;(10):46-48. [Effect of Paeonia obovata 801 on metabolism of thromboxane B2 and arachidonic acid and on platelet aggregation in patients with coronary heart disease and cerebral thrombosis].