Zilretta is an injectable suspension of a type of non-opioid corticosteroid that is injected into the affected knee joints. To assess potential effects of the systemic levels of triamcinolone acetonide associated with a single intra-articular (IA) administration of Zilretta on hypothalamic pituitary adrenal (HPA) axis function, serum and urine cortisol levels were monitored over 6 weeks post injection. with the supplied diluent. Note: Zilretta is a suspension product and it is normal for some residue to be left behind on the vial walls after withdrawing the contents. I? The safety and effectiveness of Zilretta in pediatric patients have not been established. And what's the point, if it's only for one use? You have a hereditary predisposition for osteoarthritis. In fact, my pain initially got worse after the injections. Zilretta (triamcinolone acetonide extended-release injectable suspension) single-dose kit. Monitor patients with congestive heart failure or hypertension for signs of edema, weight gain, and imbalance in serum electrolytes. Single-dose kit. However, Zilretta has saved her from constant pain. What is Osteoarthritis? Withdraw the full contents from the Zilretta vial into the syringe. Without this protective tissue, the bones rub against each other causing discomfort and difficulty moving. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Zilretta and any potential adverse effects on the breastfed infant from Zilretta or from the underlying maternal condition. If needed, the Zilretta suspension can be stored in the vial for up to 4 hours at ambient conditions. ZILRETTA (triamcinolone acetonide extended-release injectable suspension), for intra-articular use Initial U.S. Approval: 1957 _____ _____ INDICATIONS AND USAGE. The inside of both knees are worn out. A marked increase in pain accompanied by local swelling, further restriction of joint motion, fever, and malaise are suggestive of septic arthritis. Part Number: 60-009-05 Intra-articular injection may result in damage to joint tissues. Weigh potential growth effects of treatment against clinical benefits obtained and the availability of treatment alternatives. So one month to even work, then repeat in as little as 6 months. More information please phone: Attach a new needle to the syringe and remove the needle guard. The efficacy of Zilretta was demonstrated in a multi-center, international, randomized, double-blind, parallel-arm, placebo- and active-controlled study in patients with osteoarthritis pain of the knee. The average price at a hospital is. This is my 3 time to get the treatment. Last updated on Dec 1, 2022. 2015). As assessed by adverse event rates for the periods of baseline to second dose and second dose to the comparable period after the second dose, there were higher rates of reported mild to moderate arthralgia after the second dose (16%) than after the first dose (6%). The chemical name for triamcinolone acetonide is 9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene- 3,20-dione cyclic 16,17-acetal with acetone. discounted medicines and copay programs to low income or uninsured and under-insured people who meet specific guidelines. Had to go to physical therapy for several weeks & use pain medicine for several weeks. Gently swirl the vial to resuspend any of the settled microspheres prior to preparing the syringe for injection. Dermatologic: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymoses and petechiae, edema, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increased sweating, lupus erythematosus-like lesions, purpura, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A total of 470 patients (97%) completed follow-up to Week 12, the time point for primary efficacy determination, and 443 (91.5%) completed to Week 24. After about 4 or 5 months, the pain relief fades and your original knee pain returns. It is not known whether intra-articular administration of Zilretta could result in sufficient systemic absorption to produce detectable quantities in human milk. The injection is the worst thing I've ever experienced. Pain is gone and I can finally start to exercise, I have moderate osteo arthritis in both knees. Looking to reduce costs at the pharmacy counter? Zilretta (triamcinolone acetonide extended-release injectable suspension) is indicated as an intra-articular injection for the management of osteoarthritis pain of the knee. The usual technique for intra-articular injection should be followed. I can? If refrigeration is unavailable, store the Zilretta single-dose kit in the sealed, unopened kit at temperatures not exceeding 77F (25C) for up to six weeks and then discard. Tap for at least one minute until all powder is completely dispersed. Your use of this website constitutes acceptance of Haymarket MediasPrivacy PolicyandTerms & Conditions. My cost, after my insurance paid was over $2,000.00 So, basically one grand per knee, for something that is neither a quick fix, and is not long lasting at all. Metabolic: Negative nitrogen balance due to protein catabolism. In a study where 18 patients with osteoarthritis knee pain and controlled type 2 diabetes mellitus received a single IA injection of Zilretta into the knee, the change from baseline in average blood glucose over the 72 hours after injection as measured by a continuous glucose monitoring device was 8.2 mg/dL (95% confidence interval 0.1, 29.2). Why Doesn't the U.S. Have at-Home Tests for the Flu? In pregnant rats dosed with triamcinolone acetonide via intramuscular or subcutaneous injection at doses equivalent to 0.3 times the MRHD or higher during organogenesis caused developmental abnormality (cleft palate, omphalocele, late resorption, and growth retardation) and fetal mortality. Intra-articular injection of corticosteroid may be complicated by joint infection. for weeks to wait for medicare to pay for another injection. Zilretta is an injectable suspension that delivers 32 mg of triamcinolone acetonide. No notable maternal toxicity was observed in rodents. No drug-drug interaction studies have been conducted with Zilretta. Its structural formula is: MW 434.50 with a molecular formula of C24H31FO6. In December 2018, Flexion submitted for review the data on repeat administration to the FDA as part of a supplemental New Drug Application. These serious neurologic events have been reported with and without use of fluoroscopy. Valid at all major chains including Walgreens, CVS Pharmacy, Target, WalMart Pharmacy, In particular, the formulation of Zilretta should not be considered safe to use for epidural or intrathecal administration. In most cases, osteoarthritis develops slowly, but continues to worsen over time. They rated my arthritis a 3.5 with 4 being the worse. ?t wait to get my other knee injected. In animal reproductive studies from the published literature, pregnant mice, rats, rabbits, or primates administered triamcinolone acetonide during the period of organogenesis at doses that produced exposures less than the maximum recommended human dose (MRHD) caused resorptions, decreased fetal body weight, craniofacial and/or other abnormalities such as omphalocele (see Data). The last injection (in a prior course) was given at least six (6) months ago. Promptly inject Zilretta after preparation to avoid settling of the suspension. Long-term animal studies to evaluate the carcinogenic potential of Zilretta have not been conducted. Today, many physicians prescribe the drug Zilretta for people who have a decreased quality of life due to the pain and stiffness that osteoarthritis causes. In addition, more than two-thirds of patients experienced a 50% analgesic response, measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)-A (pain) score, 4 weeks after the first and second injections. My cost, after my. Version: 5, 03/2022, Zilretta Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. Dietary salt restriction and potassium supplementation may be necessary. Medicare benefits for knee injections. Now at 5 months, I am looking for a doctor to give me a shot in both knees again. Refer to the Instructions for Use for directions on the preparation and administration of Zilretta. You may be at higher risk for osteoarthritis if some of these factors are true for you: You are over the age of 60. Zilretta is the Best. Medicare.Org Is A Non-Government Resource That Provides Information Regarding Medicare, Medicare Advantage, And More. The efficacy and safety of repeat administration of ZILRETTA have not been demonstrated. In fact, my pain initially got worse after the injections. The tenth week a lot worse and by week 11 back to original bad pain and as bad as it ever was. A total of 179 patients received a repeat injection on or after Week 12 (median 16.6 weeks) and were followed for 52 weeks from the initial injection. . (triamcinolone acetonide) Attach Vial Adapter to Zilretta Powder Vial. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Package insert / product label I gave 2 stars on ease of use since the injections were painful to get. Note: Zilretta is for intra-articular use only. I have been living with almost constant bilateral knee pain. One vial of Zilretta white to off-white microsphere powder, Serious Neurologic Adverse Reactions with Epidural and Intrathecal Administration. Among the examples listed for drugs covered by Part B is injectable or infused drugs. Significant improvement in pain and functional capacity from the prior series of injections is documented in the medical record; and. Nonsteroidal anti-inflammatory drugs (NSAIDs). 3 months and going strong. 67 year old male. A properly mixed suspension will be milky white, contain no clumps, and move freely down the vial wall. The result is painful, swollen and stiff joints. Inspect for bubbles with the syringe held in a completely vertical position (needle upward). Medicare.Org Is Privately Owned And Operated By Health Network Group, LLC. View generic Zilretta availability for more details. Zilretta is not interchangeable with other formulations of injectable triamcinolone acetonide. General and administration site conditions: Pain including injection site pain or discomfort and leg pain. Zilretta is supplied as a single-dose kit containing a vial of Zilretta microsphere powder, a vial of sterile diluent, and a sterile vial adapter. Zilretta is administered as a single intra-articular extended-release injection of triamcinolone acetonide, to deliver 32 mg (5 mL). As people age, the daily wear and tear on the bodys joints, especially the knees, causes the loss of cartilage and inflammation. Without Part B Medicare benefits, your out-of-pocket costs for one dose of Zilretta is over $600.00. It is a corticosteroid that your doctor injects into your knee joints. Now patients like me can get durable long term pain relief. Must be reconstituted Infection and discomfort at the site of the infection are possible side effects. It lasted almost 4 months. Drugs like Zilretta work by blocking the substances within the body that can cause inflammation. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. The orthopedic Dr. who did them said that Zilretta can take up to a month to even work, and you need the injections repeated every 6 to 8 months. A friend told me about how much Zilretta had been helping her with pain relief. If you have been wondering about whether Zilretta is right for you, or if your Medicare benefits cover its cost, here are some of the facts. For additional information, visit www.Zilretta.com or call Pacira Pharmaceuticals, Inc. at 1-844-353-9466. Zilretta gets an A . Read More Read Less. The Cleveland Clinic, a non-profit academic medical center in Ohio, provides information in their health library on four injections that may reduce inflammation and lessen joint pain. Local injection of a corticosteroid into a previously infected joint is not usually recommended. Use proper aseptic technique throughout the dose preparation and administration procedure. Eliminate all bubbles by slowly depressing the plunger to displace the air from the syringe. I hope it helps you and your friends. 844-353-9466 I only wished the pain relief started sooner. Rare instances of anaphylaxis have occurred in patients with hypersensitivity to corticosteroids. 1), Medical-grade gloves (not shown in Fig. g. Zilretta (triamcinolone acetonide extended- release) is an extended-release intraarticular corticosteroid - injection indicated for the management of osteoarthritis pain of the knee. Promptly inject Zilretta after preparation to avoid settling of the suspension. Osteoarthritis is the most common type of arthritis and it most commonly affects the knees, hips, hands, and the spine. No peri- and post-natal development studies of triamcinolone acetonide in animals have been conducted. 1). Medicare benefits for knee injections There are a number of medicines that can interact with corticosteroids such as triamcinolone acetonide. Single administration resulted in a slightly increased incidence, severity (minimal to slight), and/or duration of microscopic changes (infiltration of macrophages, lymphocytes, plasma cells and fibrosis) and decreased Safranin O staining (decreased proteoglycan content in the cartilage of the knees) compared to administration of an equivalent dose of immediate-release triamcinolone acetonide. She? All she talks about is how great Zilretta isso I asked my doctor what is opinion is. Invert the syringe several times to ensure a properly mixed suspension. Tap the vial until excess powder is dislodged from the vial and stopper (Fig. Medicare reports that patients pay an average of $84 for injections of therapeutic substances, such as cortisone, when performed at a non-hospital facility. 5 mL single-dose vial to deliver 32 mg of triamcinolone acetonide supplied as a sterile, white to off-white powder in a cerium glass (clear) vial with a rubber stopper and an aluminum seal with a gray plastic cap. As shown in Figure 3, the vial on the left, with the X, requires additional tapping because the powder is not properly dislodged. However, corticosteroids have been detected in human milk and may suppress milk production. After Zilretta, I can focus on enjoying activities like walking and fishing. Intra-articularly injected corticosteroids are systemically absorbed. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. A Non-Government Resource For Healthcare All Rights Reserved 2023. As in the PRP injections, there is a potential for infection and soreness at the injection site. The Coverage and Analysis Group at the Centers for Medicare and Medicaid Services (CMS) requested from The Technology Assessment Program (TAP) at the Agency for Healthcare . Repeat administration of Zilretta (triamcinolone acetonide extended-release; Flexion Therapeutics) appears to be safe and well-tolerated in patients with osteoarthritis knee pain, according to results from a Phase 3b study. Carefully observe pediatric patients, including weight, height, linear growth, blood pressure, intraocular pressure, and clinical evaluation for the presence of infection, psychosocial disturbances, thromboembolism, peptic ulcers, cataracts, and osteoporosis. Zilretta is an FDA-approved treatment for knee pain caused by osteoarthritis. Published studies on the association between corticosteroids and fetal outcomes have reported inconsistent findings and have important methodological limitations. The inside of both knees are worn out. Dietary salt restriction and potassium supplementation may be necessary. I tried it and I am very very happy. I got the injections done to both knees at the same office visit. 4). Immune system: Hypersensitivity reactions including pruritus, rash, angioedema, and anaphylaxis [see Contraindications (4), Warnings and Precautions (5.3)]. Table 3 contains drug interactions associated with systemic corticosteroids. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Of all the joints in the human body, the knee joint is the largest, most complicated and most susceptible to injury. WHAT DO YOU HAVE TO PAY FOR THE INJECTIONS?? I am super satisfied with Zilretta. Since osteo arthritis is degenerative, I'm sure a total knee replacement is in my future. So one month to even work, then repeat in as. The adverse effects of corticosteroids in pediatric patients are similar to those in adults. Some of the symptoms of osteoarthritis include: Pain in the affected joint during movement or at rest after movement. Eligibility requirements vary for each program. Left knee is bone to bone on inside. Note: At least one minute of tapping and gentle swirling is required to achieve uniform suspension. If your 61years old with bone on bone OA, it??s a little disingenuous to expect Zilretta to join the Olympic Gymnastics team! If you have Part B, your Medicare benefits will likely pay 80 percent of the Medicare-approved amount of these prescription drugs. Osteoarthritis occurs as the result of the wearing down of the protective cartilage between the joints. ZILRETTA is an extended-release synthetic corticosteroid indicated as an intra-articular injection for the management of osteoarthritis pain of the knee. The majority of published literature with corticosteroid exposure during pregnancy includes the oral, topical and inhaled dosage formulations; therefore, the applicability of these findings to a single intra-articular injection of triamcinolone acetonide is limited. I have moderate osteo arthritis in both knees. 12). Arachnoiditis, meningitis, paraparesis/paraplegia, and sensory disturbances have occurred after intrathecal administration. For more information, go to Zilretta.com or call 1-844-353-9466. Ophthalmic: Exophthalmos, glaucoma, increased intraocular pressure [see Warnings and Precautions (5.9)], posterior subcapsular cataracts, rare instances of blindness associated with periocular injections. The vial on the right shows the powder properly mixed and ready for the next step. Medicare Part B benefits may apply to certain drugs obtained in a doctors office or hospital outpatient facility. She tried Zilrettazabout a year ago. It binds to and activates the glucocorticoid receptor, leading to activation of anti-inflammatory transcription factors such as lipocortins and inhibition of inflammatory transduction pathways by blocking the release of arachidonic acid and preventing the synthesis of prostaglandins and leukotrienes. If an aspiration and an injection procedure are performed at the same session, bill only one unit for CPT code 20610 or 20611 (if applicable). Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect. Amphotericin B injection and potassium-depleting agents. I gave 2 stars on ease of use since the injections were painful to get. Any excess suspension in the vial should be thrown away immediately after the injection. Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. This steroid offers a reprieve from symptoms for two to three months. The adapter will snap into place. What pain relief! Clean the Zilretta powder and diluent vial tops with an alcohol pad. Drugs which induce hepatic microsomal drug metabolizing enzyme activity may enhance metabolism of corticosteroids and require that the dosage of corticosteroid be increased. Your physician may suggest appropriate activities that may include walking, swimming, water aerobics, cycling on a stationary bike, elliptical equipment and tai chi. Your health care provider will inform you whether you are a good candidate for this type of therapy. These opinions do not represent the opinions of WebMD. Repeat administration resulted in an increase in the incidence, severity (minimal to slight) and duration of microscopic changes (infiltration of macrophages, lymphocytes, plasma cells, neutrophils; fibrosis; neovascularization; granulation tissue; and debris) and decreased Safranin O staining (decreased proteoglycan content in the cartilage of the knees) compared to the equivalent dose of immediate-release triamcinolone acetonide. It is a corticosteroid that your doctor injects into your knee joints. If bubbles are observed, gently tap the syringe with your finger until the bubbles rise to the top. While it has repeatedly worked perfectly for 10 weeks I still have to suffer for weeks to wait for medicare to pay for another injection. Note: All new enrollment is now done electronically or over the phone. There are no data regarding the use of Zilretta in pregnant women to inform a drug associated risk of adverse developmental outcomes. No notable maternal toxicity was observed. Single and repeat administrations (one injection every three months for a total of three injections) of Zilretta in non-arthritic knee joints of healthy dogs have been studied at ~1.9 times the maximum recommended human dose (MRHD) of 32 mg (based on estimated drug concentrations within the knee joints). The free Drugs.com Discount Card works like a coupon and can save you up to Attach the syringe onto the vial adapter by pushing down and turning clockwise until you feel resistance (Fig. Clobetasol vs. triamcinolone - how do they compare? Corticosteroids may also mask some signs of current infection. Note: This is a drug discount program, not an insurance plan. Zilretta Inspect all kit components to confirm they have not expired and the seals are intact. Medicare and supplement insurance paid for it in full. Trademark of Pacira Therapeutics, Inc., a wholly owned subsidiary of Pacira BioSciences, Inc. 2022 Pacira Pharmaceuticals, Inc. All rights reserved. Since osteo arthritis is degenerative, I'm sure a total knee replacement is in my future. To evaluate the safety and tolerability of repeat administration, a Phase 3b single-arm, open-label trial was conducted in patients with symptomatic OA of the knee including those with advanced disease. Available for Android and iOS devices. ?s even a candidate for total knee replacement. The vial on the right shows the powder properly dislodged and ready for the next step. Pregnant mice dosed with triamcinolone acetonide via intramuscular or subcutaneous injection at doses equivalent to 0.8 times the MRHD or higher during organogenesis caused cleft palate and a higher rate of resorption. Do not expose the Zilretta single-dose kit to temperatures above 77F (25C). 7). The syringe must remain on the vial adapter while the suspension remains in the vial. Medicare Part B (Medical Insurance) covers podiatrist (foot doctor) foot exams or treatment if you have diabetes-related nerve damage, or need. I cannot afford to pay for it as it is very expensive. We comply with the HONcode standard for trustworthy health information. I knew after the 1st right knee was done, but my doctor insiste. Drugs like Zilretta work by blocking the substances within the body that can cause inflammation. While there is no cure for osteoarthritis, there are ways to slow its progression, like losing weight, eating a healthy diet, and getting gentle exercise. Triamcinolone acetonide is a corticosteroid with anti-inflammatory and immunomodulating properties. Tap the bottom edge of the vial firmly and repeatedly, in a circular motion, on the padded surface. Examine any joint fluid present to exclude a septic process. Most people do not pay a premium for Medicare Part A because they have paid enough Medicare taxes during their working life. No pain. Patients had a mean age of 62 (range 40 to 85 years); baseline demographics and disease characteristics were balanced across treatment arms. The efficacy and safety of repeat administration of Zilretta have not been demonstrated. Please contactMedicare.govor 1-800-MEDICARE (TTY users should call1-877-486-2048) 24 hours a day/7 days a week to get information on all of your options. Although the majority of seniors over 70 will experience joint pain, there are lifestyle changes that may help. Remove the needle from the syringe containing diluent. Stiffness, especially in the morning or after sitting for a while. Inspect the Zilretta powder vial to ensure no clumped powder is visible and a uniform suspension has been achieved. I participated in the 2nd phase study for consecutive shots in my left knee. After 1 week,of getting a shot in both knees, I felt like Superman. Concomitant use of aspirin (or other nonsteroidal anti-inflammatory drugs) and corticosteroids increases the risk of gastrointestinal side effects. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. As shown in Figure 6, place the Zilretta powder vial on a flat surface. Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia. Osteoarthritis, the most common joint disorder in the United States, affects the knee joints of 10 percent of all men, and 13 percent of all women over the age of 60. Copyright 2023 Haymarket Media, Inc. All Rights Reserved The data below reflect exposure to a single 32 mg intra-articular injection of Zilretta in clinical studies in patients with moderate to severe pain due to osteoarthritis of the knee. No effect on the animals according to observations related to gait/walking, pain/discomfort in the injected knee, local swelling, local redness or local tenderness were noted. Studies indicate that following a single intramuscular dose of 60 to 100 mg of immediate-release triamcinolone acetonide injectable suspension, adrenal suppression occurs within 24 to 48 hours and then gradually returns to normal, usually in 30 to 40 days. They never last longer that a month or so especially if I do vigorous workouts. It worked very well on my left knee within one week. Tenderness when light pressure is applied. 2005 - 2023 WebMD LLC. Patients on prolonged corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response. Zilretta demonstrated a statistically significant reduction in pain intensity at the primary endpoint vs placebo. Platelet-rich plasma (PRP) injections are intended to change the immune response by using the patients own blood and platelets. The orthopedic Dr. who did them said that Zilretta can take up to a month to even work, and you need the injections repeated every 6 to 8 months. Before continuing, ensure that powder moves freely within the vial. Manufactured for Pacira Pharmaceuticals, Inc., a wholly owned subsidiary of Pacira BioSciences, Inc. San Diego, CA 92121 USA. Advise patients who have not been vaccinated to avoid exposure to chicken pox or measles. Therefore, look to Part B for Medicare benefits, which covers drugs that individuals would not normally give themselves. Convulsions have been reported with this concurrent use. or obtaining a sample from the doctor's office. Approval of Zilretta was based on the results of a double-blind, 24-week trial in 484 patients 40-85 years old with moderate to severe knee OA pain who were randomized to receive triamcinolone acetonide ER 32 mg, saline placebo, or a standard crystalline suspension of triamcinolone acetonide 40 mg (active control). In this study, all participants will receive an intra-articular glenohumeral injection of ZILRETTA and will be followed up with at four time points over 1 year to observe pain, function and range of motion following the injection. However, don??t expect miracles and then bad mouth the drug. Zilretta is supplied as a single-dose kit, containing: Zilretta is contraindicated in patients who are hypersensitive to triamcinolone acetonide, corticosteroids or any components of the product [see Warnings and Precautions (5.3) and How Supplied/Storage and Handling (16)]. A total of 484 patients (Zilretta 32 mg, N=161; placebo [saline], N=162; active control [a crystalline suspension, immediate-release formulation of triamcinolone acetonide 40 mg], N=161) were treated and followed for up to 24 weeks. We comply with the HONcode standard for trustworthy health information. With a syringe and needle, withdraw 5 mL of diluent. When corticosteroids are administered concomitantly with potassium-depleting agents (i.e., amphotericin B, diuretics), observe patients closely for development of hypokalemia. They decided against doing a total knee replacement due to my age. These responses were mostly reversed after 6 to 9 months post injection. 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions. Swelling that is usually from inflammation of the soft tissue around the joint. Now at 5 months, I am looking for a doctor to give me a shot in both knees again. data become available, Zilretta does not receive a favorable recommendation. 2 DOSAGE AND ADMINISTRATION I have been living with almost constant bilateral knee pain. Zilretta is proven and medically necessary for the treatment ofOsteoarthritis pain of the knee when all of the following criteria are met: Diagnosis of osteoarthritis pain of the knee; and I have been suffering from itb pain following a hip revision. Zilretta is prepared with a supplied diluent containing an isotonic, sterile, aqueous solution of sodium chloride (NaCl; 0.9% w/w), sodium carboxymethylcellulose (CMC; 0.5% w/w) and polysorbate-80 (0.1% w/w) to form a 5 mL sterile suspension intended for intra-articular injection.
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