I mean, my mom, my mom and my dad, I got my whole family. Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology. Percent of patients that died with covid-19 were vitamin D deficient. My guest today is a treasure, one of the smartest human beings I've ever met. Wow. At work. Why is it OK? Right. We've got to be careful. I don't want to be manufacturing a take or trying to, like, come up with some sort of a hot take on how I feel. And one of the first experiments I had that I was doing, like one of my first projects was. But they're in there for like an hour, you know, and they're getting they raised their core body temperature. And he's like, no, I go, listen, I have to go, but you got to do something about it. That's the antidepressant effect like that. It was, it was like, OK, now, now we're cooking and I was sweating up a storm. That's a giant factor in your immune system. I mean stuff goes wrong. So you have memory B cells that are making antibodies that are specific to bind different regions, epitopes on the virus and neutralize them, prevent them from getting inside of the cell. It is. I guess it was non significant for whatever reason. Hey since you're using that to justify disparaging it, you should explain to everyone here how all of that is pertinent to this study specifically. Better skip this one. So I mean, I guess they're called Finnish Sana's, which means like they're using the hot water and steam. So, you know, my heart rate it it can get up to like 120. And went to Russia to have some sort of crazy medical detox. They just vaccinate. But, you know, you kind of just take it with a grain of salt where these clots are like, you know, there's clots in people that are healthy and young, certainly people that have severe cases, people like older people, people that are pre-existing conditions and stuff, and the type of blood people have lower levels of this Vaun Gillibrand factor, which basically is involved in clotting. That's a theory that hasn't been shown. Yeah. And it's thought because the type of antibodies that people with type O blood make neutralize the they basically bind to that region, that spike region and neutralize the antibody and prevent it from the virus from entering the cell. Everyone wants randomized control trials like no one wants to believe anything until it's a randomized controlled trial. It's known that the antibodies bind there and neutralize that. You were going to be totally shocked. And it's like, yes, it's very addictive. Oh, can I, can I exploit rock pools. The problem is antibody dependent enhancement, so sometimes a neutralizing antibody is an antibody that can bind the virus and neutralize it, stop it from entering your cell, right. They even operated during the prohibition with a permit to make whiskey for air quotes, medicinal purposes. So you're basically like you're you're becoming adapted. You just I couldn't come to an answer. Oh yeah. And the United States published an article this week in the journal Cell that highlights the potential use of Lamba antibodies to prevent covid-19 infections. Yeah. I would do I would do my yoga or my ballet and then I would run. Vitamin C somewhere thottam. That's the reason I do it. But also it's been shown that the hydrogen peroxide does not damage the normal cells like normal northie normal healthy people. In the Indonesia was a really interesting study where, like, they measured vitamin D and this was measured in the patients. But that's been probably the biggest thing, by the way. OK, right. And it's like the first time I ever went camping and it was like snow camping. He's like, they're totally gone. And it was like blowing my mind like percent like what's going on? I mean, the blacks, they're basically living in England and Wales are four times more likely to die of covid-19 than than whites when they when they adjusted all that data for socioeconomic status and for other health factors, there were two times more likely to die. So there's lots of things. It's like like three hours before shelter in place was put in California. I'm just like, you know, there's I'm not scared. But there's other companies that have isolated from humans that have been infected. And that's also that's also known, you know, so I think all those things and then the sleep. Right. I'm not hearing anything about methods, nutrition that boosts your immune system. It has like a little tongue depressor. You should judge, but I have a hard time. I like life, had friends that are physicians that have like, you know, in New Orleans, I mean, the same thing where it's like a you know, there was someone on my team. It plays a big role in protecting that's been shown in multiple studies like. All right. But we have a terrible recipe, right. Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc. I was like, told you, told you motherfucker. Yes. I think social distancing makes sense. Dr. Patrick goes into detail on the Vitamin D sweet spot and its effect on anti-aging below. So you take 200 milligrams. There is also existing knowledge suggesting vitamin D may have a critical role in the regulation of the immune system which might include viral infection immune responses. You're entering into prison. But what is known is that people with type of blood are are less susceptible to contracting covid-19 that's that's definitely known. She has heavily investigated the role of Vitamin D on brain function, behavior, hormones, and immune function. Because they're one of the sponsors of the podcast. I did a sleep study once because of sleep apnea. I mean, they're burning. So I think. It's like a market difference. They have produced more than two million liters of hand sanitizer so far, and they're still making bourbon as well, rolling it more barrels into the warehouses every day. This is something that your body can generate naturally if you're exposed to the sun on a daily basis. Don't go outside. So he tracked proteins also do have antiviral activity against at least influenza A.. So anybody's working the late shift. I mean those aren't those are Breece Mark Levine at the NIH. I wanted to tell you this Xyloto. Just constant wear for years then. So there's a lot of people in the United States, as you mentioned, you make it from the sun. You can. Our bodies have been around longer than office buildings. And in fact, because the zinc is bound to fight weight, it's less bioavailable. I'm glad I don't have that. You know, you're breathing. But CBD, amd, the company that I use, what I really like is they have a bunch of muscle creams and like, you know, stuff that you rub on the outside of your muscles. Enough once a week is enough. Right. I mean, there's been some small studies looking at you're talking about performance enhancements. Before I was off and I also choke. Like there's huge variations in the results and it all really seems to come down to dose like it really does. Please give it up for the great and powerful Dr. Rhonda Patrick Girlyman podcast, The Joe Rogan Experience, trained by day Joe Rogan podcast, My Night All Day. It's a two person sauna and. And like like he had been reading some studies to confirm that. And so there some people paid extra to like go to this event that. We drink it all the time. I mean, like I said, ours is really small. And Japan has a very low mortality rate, correct? And you live in you live in San Diego. No, no, no. I haven't done. The ones that you plug in. You know, the biggest thing that really affected my glucose levels wasn't popcorn. There was 10 percent less likely. Yeah. And it it it had a pretty powerful antidepressant effect, very similar to Charles Raisen study with the hyperthermic chamber thing. Right. And they want to just they want to shoot people down, make people feel bad and just don't. Rhonda Patrick's Comprehensive Joe Rogan Experience Notes Suppose you've enjoyed any of Dr. Patrick's Joe Rogan Experience appearances. She's like, fuck off staying awake. I don't remember what it was. It was like a huge thing. We're Kimche. Yeah. Rhonda has mentioned the Nordic Naturals brand on . I like, you know, like so. And since Legal Zoom is not a law firm, you do not have to worry about expensive billable hours adding up. Right. And can you take too much vitamin D? What about cold shock proteins and the I mean, how much difference is it between taking a really cold shower ice bath versus something like krail cryotherapy, like the place that I took you to. So the xylitol gum somehow. It's higher in people with sars-cov-2. Monthly didn't work there. And so it creates humidity. Sign up for an annual subscription and receive an additional 15% discount. That's it. It bothers me when people like, well, then don't go on Twitter, period, because most people are unhappy or YouTube. They were getting some kind of green light therapy or whatever, you know, so it was a placebo control because the placebo effect is definitely a real particularly with depression. A couple things you put on your head. And then I'm like in this weird loop that my own brain creates which is really bad that I'm very addicted to trying to conquer things. I've seen a guy who wears one of those, but he's diabetic. So it's that Bertsch you know what they're whipping. 3. It is hard. It's freezing out here in Finland in November. Tastes better. I thought that was really interesting. He's still suffering from it. We were like you early on. Yeah, it's. Hopefully people are going to start looking at the vitamin D. I really like that. I would say that it's the marketings got a little ahead of the science for that. I think it's important to be critical. The weight is behind you. Nootropics. I hate that it is so terrible. I guess maybe that that's why I've even heard people dismiss vitamin C saying that your body only absorbs a certain amount. Yeah. There is a possibility supplementing with vitamin D can decrease the severity of the COVID-19 infection and eliminate the need for hospitalization. So like in combination with some of this other stuff, like from days of yore, which is, you know, it's not like a silver bullet, but it seems like it's also promising, promising probably with a combination of other other factors as well. The Joe Rogan Experience #1178 - Dr. Rhonda Patrick. Like, I want to get I need to like I need a measurable like I need something to measure. That makes you feel good every day. It's something in the environment. So so the problem is, is that calcium can easily form a precipitate in in in general and particularly when phosphorus is around and phosphorus is. It's no I used to but then there they are. Yes. And and I was like. And I and I didn't sort of dive into the whole thing, but he was he was telling me that ventilators do actually cause more damage to the lungs. Posted on I need to go to hospital. Woo woo. So it's the study concluded that they're both the same, but it seems as though astate maybe slightly better, maybe slightly better. The other thing that happens is the antibody binds to the virus, doesn't neutralize it, but it like makes this crazy immune complex that, like, activates your immune system to just go haywire and it causes all sorts of pathology. The dark one. Two hundred milligrams. And and there's a there's like a theory going around because that specific region, it's been shown in sars-cov-2 one to cause antibody dependent enhancement. He's given us gave us this new platform too. Like to get a wub strap because the strap was no problem at all. Watch the sunrise or sunset. But I was also using the gym sonas. So that is crazy. And I used it for a long time. Yeah. And I don't know, I got to, like, do some more reading because, like, it's not that's not uniform. I've only done the cryo. But the interesting thing about vitamin C is, you know, there's oral and then there's intravenous vitamin C and the intravenous vitamin C is what's with seems to be really relevant right now. Well I think we covered a lot today. So some people prefer ice baths. Affecting the aging process. So there's studies there's been some large scale and genetic studies that have found that Asians, about 20 percent of Asians have a basically a nucleotide change in a gene that encodes for a protease that's involved in this, you know, basically in allowing this virus to get into the cell. Find someone to find some gal who's fucking jacked and knows how to lift weights, you know, and then I'll inform them all about the sauna and tell them I'll be fine if it's on us. But when you say an antidepressant, there's no real way to measure that. And I know people are. I hope. I don't want to make people feel bad. I did. Right. I mean, these things also affect the immune system, which is also very relevant, both cold and bright and hot. Right. He's like, that's bad. By that I think so they were. So so there's like all this there was all these conclusions. And they're still winning. Transcript and discussion of #1474 - Dr. Rhonda Patrick from The Joe Rogan Experience podcast. They're not just like, boom, full stop going to, like, increase something when everything's normal. Even if even if they're wrong, they just love to, like, fixate on confirmation bias. Like, you know, I mean, for you personally, for just for health benefits. It's just going to overall improve the way you age and that's going to make you more robust and resilient to anything, you know. You know, that people think like when you tell them, go sit in the sauna, they think of like a spa, like, yeah, I want to go do that. But I do think that there's there's promise, particularly for some treatments. What does the cytomegalovirus. So I tell you my story Zettl is it's like from Burchett's from the Bertsch plant we were just talking about. You know, it's well, it's it's important. I mean I guess eventually I was doing we were in there, I was in there for I don't know how long and then I'd go in the ice and then go back in there but I would get out and I would collapse. And like I remember, I like shared this animal study in an article I wrote years ago before the human study came out. I have really tiny ear canals and I just like I can't some people can sleep with earplugs, like I just can't. So it's a lifelong thing. What is measured most of the time with cold shock is norepinephrine, release and norepinephrine in plasma. I mean I mean, it's just kind of a mess where initially it seemed like it could be helpful. So she right now, her name is Doctor. And and then just more and more studies came out where it was not not only not helpful, it was, you know, toxic. Big 12 shots. It's so there's so many variables in terms of like how people how people are affected by it and what goes wrong, because there are so many variables. Rhondas optimal dosage is 5,000iu daily. There's a lot of researchers out there trying to, like, figure out if genetics is involved in this. Right. Wow. Yeah. But right now it's like there's no gyms that are open. Do I do a hundred and eighty degrees for twenty five minute, dude? Kind of weird how there are so many people proposing the OP/study is a shill for vitamin companies, and trying to refute the study based solely off the OP advocating Vitamin D in his post history when you can get substantial amounts of Vitamin D3 from fish, milk, or y'know being out in the sun. And I think people will become less scared as these as these therapeutics do emerge, which which which they will, I'm sure. Yeah, there's been sampling where you like you go to like Walgreens or CVS. So there's been studies were like you could do a two minute cryo, whatever the average temperature, it's really cold, minus two for it is something like that. All right. Vitamin D activates the innate immune system, which elicits an early antiviral response. But you're on this platform and all the weight is on this belt instead of on your shoulders. So it's like it's a lot of weight that your muscles are pushing down is always trying to get me to do squats like I don't know what. And there has been studies correlating norepinephrine in plasma upon cold exposure, norepinephrine release and plasma to in the brain where it's involved with like mood and focus and attention. He will. And this it was happening in March. But scroll back up to the to the main home. So I'm taking nine milligrams a night. You just you get like sometimes when I get nervous, my eye will start watering. But also maybe that is not feeling well because vitamin D deficiency plays a factor in that as well. Sugar that the sugar and that one's too much. I don't to but boy I wear a continuous glucose monitor. That the monoclonal antibody you were talking about, the Lomis. And I think that that I think that eventually there's going to be therapeutics that are identified, you know, not multiple ones maybe. There's been studies correlating it with seasonal affective disorder and all that. Right. Yeah. I don't stop at all. I mean it was like I finally got a jump rope and it came in right when the beaches opened up. So that's so bad. Thanks so much for having me back on Park. So, you know, we call the first I call the ambulance. So like after the onset of symptoms. Yeah. Some notes from her podcasts on the JRE. What if what if, you know, some some common cold coronavirus has gone around and that, you know, those antibodies that they've made to neutralize that coronavirus beta coronavirus are somehow helping with the sars-cov-2 like. Yeah, obviously it's in your body, but when you if it's in your nostrils or if it's in your respiratory tract and you're breathing in that heated sauna air, does that have any effect at all on on viruses? Well, some of them, they have poor people, especially in the beginning when you're seeing these people that were like using makeshift masks and just trying to. They're never going to forget how weird this is to do in all their classrooms on iPads. When we were talking about song, when people that don't have access to a sauna, how much benefit can they get out of a hot bath? So I get back into the sauna and and like, getting back into this like two hundred and ten or twenty degrees on it. I use a day. That's what I mean. No, it's the popcorn. At the same time, it's also acting as an antioxidant for for your own neutrophils. That's one thing that they're investigating. I've got two publications on it. I mean, I'm sure I do lots of announcements there. Subscribe to our channels. I think, you know, that hasn't really been studied. Oh okay. Mine's mine's right here.
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